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Past Challenges

Explore previous challenges and collaboration opportunities.

Plant-derived insulator elements for predictable gene expression

Plant-derived insulator elements for predictable gene expression

FOCUS AREA: Enabling Technologies

The ability to effectively and efficiently improve crops through genetic engineering relies on finely tuned expression of integrated genes that is predictable in varying genetic backgrounds.  However, the structural organization of the eukaryotic genome is complex.  The expression of a gene is not only influenced by its associated regulatory elements but may also be affected by regulatory elements of nearby genes or by transcriptional interference between genes.  One strategy for improving the predictability of gene expression is to use insulator elements to shield gene expression from outside influence. 

Non-destructive, in-field measurement of corn stalk integrity

Non-destructive, in-field measurement of corn stalk integrity (collaborating)

FOCUS AREA: Enabling Technologies

Every year stalk rot diseases and stalk boring insect infestations can result in serious damage to corn crops and significant yield losses. Current methods to evaluate resistance of corn varieties to stalk rots and borers require manual splitting of stalks and visually assessing or measuring the amount of internal stalk damage. These methods are not only labor and time intensive, but also can result in qualitative scoring and the destruction of valuable plant material. The ability to assess the internal integrity of corn stalks and the level of resistance to disease infection or insect damage in a rapid, non-destructive manner in the field would accelerate the generation of new resistant corn varieties.

 

Innovation for Disease Resistance

Innovation for Disease Resistance

FOCUS AREA: Enabling Technologies

Each year, plant diseases cause an estimated 40% yield loss worldwide in the most important food crops.  Our goal at Corteva Agriscience™, Agriculture Division of DowDuPont is to develop robust, sustainable and durable solutions to crop disease problems. Our strategy relies on an integrated approach to disease control:  stacking native disease traits with transgenic traits; applying CRISPR-Cas genome editing technologies to accelerate development of resistant plant lines; combining genetic solutions with chemical and/or biological products for comprehensive control.  We invite public and private sector scientists to join in our efforts with innovative approaches that will help tackle and find solutions to the most important global crop diseases.

 

Genome Editing for Crop Improvement

Genome Editing for Crop Improvement

FOCUS AREA: Traits

At Corteva Agriscience™, we are leaders in CRISPR-Cas research for agricultural products, especially for crops including maize, soybean, canola, wheat, and sorghum. Because we believe in the potential of CRISPR-Cas to improve crops, we are dedicated to enabling the broader research community and encouraging wide adoption of CRISPR-Cas in agriculture. By facilitating access to the technology, we intend to help solve some of the world’s biggest food security challenges. 

Enhancing Genome Editing Using Repair Templates

Enhancing Genome Editing Using Repair Templates

FOCUS AREA: Traits

We are interested in developing partnerships with outstanding academic scientists to pursue advancements in template-based CRISPR-Cas genome editing. Homology directed repair (HDR) approaches enable defined sequence changes and insertions by utilizing donor templates to instruct cellular repair of a CRISPR-Cas induced break of genomic DNA. Achieving HDR in plants requires generating and screening hundreds of plants with success rates varying among experiments. To help realize the potential of genome editing we recognize the need to support innovation with monetary grants, access to leading-edge technologies, and knowledgeable collaborators.

Insect Midgut Epithelial Cell Culture

insect midgut epithelial cell culture systems

FOCUS AREA: Enabling Technologies

Cell cultures are used in many fields of biological research to look at cellular responses to external inputs. They can serve as a predictor of responses by the whole organisms from which they were derived.  In the field of entomology, several types of cell-based assays have been used successfully to characterize cellular responses.  In many of the described cases, the cell-based assays utilized recombinant techniques within cell lines to recreate the physiological target of an input. Alternatively, cell lines derived from non-midgut tissue that happened to be naturally susceptible to an insecticidal protein were used.

Natural Products or Natural Product-Derived Small Molecules

natural-products

Corteva AgriscienceTM is seeking pure natural products and semi-synthetic natural products for pest control. Material supply of compounds which are natural products or natural-product derived small molecules is desired. Crude extracts and mixtures are not requested for this Challenge.

Methods for Determining Similar Sequences Across Genomes

plant-allelic-determination-image-square

At Corteva Agriscience™, we develop robust and sustainable agriculture solutions and drive innovation through technologies including genomics.  

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